{"id":2173,"date":"2022-05-18T10:00:00","date_gmt":"2022-05-18T01:00:00","guid":{"rendered":"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/?p=2173"},"modified":"2025-12-09T13:25:24","modified_gmt":"2025-12-09T04:25:24","slug":"mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022","status":"publish","type":"post","link":"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/","title":{"rendered":"Mediplus Pharma is presenting posters at Society for Investigative Dermatology\uff08SID\uff09annual meeting 2022"},"content":{"rendered":"\r\n

Mediplus Pharma, Inc. (CEO: Kenji Ito, Head Office: Shibuya-ku, Tokyo,JAPAN) made a scientific presentation at the annual meeting of the Society for Investigative Dermatology<\/a> (May 18-21, 2022, Portland, USA), which is considered the world’s highest-level society in dermatological research.<\/strong><\/p>\r\n\r\n\r\n\r\n

Title\uff1aNovel glycerin compounds improve skin health<\/strong><\/h3>\r\n\r\n\r\n\r\n

<\/p>\r\n\r\n\r\n\r\n

\r\n
\r\n

Digest<\/strong><\/h2>\r\n\r\n\r\n\r\n

Novel glycerin compounds (NGCs) were developed which generated new reaction products. NGCs have been reported to exhibit various biological effects. This study is aimed to evaluate the effects of NGCs on skin homeostasis<\/a> by investigating antioxidant activity and barrier functions. NGC enhanced expression of HO-1, NQO1 mRNA<\/a> and GSH protein in a concentration-dependent manner from 20 ppm after 24 h of stimulation. These results imply that the oxidative property of NGCs activates Nrf2 (NF-E2-related factor 2)<\/a> transcription factor, which is a biological defense sensor, and induces the expression of antioxidant factors. It was strongly suggested that their hormesis<\/a> effect would be working protectively for the skin. Mild oxidative stimulation of NGCs could lead to healthy skin through their hormesis<\/a> effect on antioxidant activity and barrier functions.<\/p>\r\n<\/div>\r\n\r\n\r\n\r\n

\r\n
\"\"<\/figure>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n

Background<\/strong><\/h2>\r\n\r\n\r\n\r\n

Novel glycerin compounds (NGCs) were developed which generated new reaction products. NGCs have been reported to exhibit various biological effects. In addition to their deodorizing, disinfecting and antiviral effects, NGCs were found to increase type I collagen<\/a> production and inhibit pro-inflammatory cytokine<\/a> secretion.<\/p>\r\n\r\n\r\n\r\n

Purpose<\/strong><\/h2>\r\n\r\n\r\n\r\n

This study is aimed to evaluate the effects of NGCs on skin homeostasis<\/a> by investigating antioxidant activity and barrier functions.<\/p>\r\n\r\n\r\n\r\n

Method<\/strong><\/h2>\r\n\r\n\r\n\r\n

In this study, in order to clarify the effects of NGCs on normal human skin, we quantified the mRNA<\/a> gene expression of heme oxygenase-1 (HO-1)<\/a> and NAD(P)H:quinone reductase1 (NQO1) as antioxidant factors by PR-PCR<\/a> and the protein content of intracellular glutathione (GSH) <\/a>using a culture system of normal human epidermal keratinocyte. Moreover, gene expression of factors related to skin barrier functions<\/a> (involucrin (INV)<\/a>, filaggrin (FLG)<\/a>, and serine palmitoyl transferase (SPT)<\/a>) was examined to clarify the effects of NGCs on epidermal cell differentiation.<\/p>\r\n\r\n\r\n\r\n

Results<\/strong><\/h2>\r\n\r\n\r\n\r\n

NGC enhanced expression of HO-1, NQO1 mRNA<\/a> and GSH protein in a concentration-dependent manner from 20 ppm after 24 h of stimulation. These results imply that the oxidative property of NGCs activates Nrf2 (NF-E2-related factor 2)<\/a> transcription factor, which is a biological defense sensor, and induces the expression of antioxidant factors. It was strongly suggested that their hormesis<\/a> effect would be working protectively for the skin.<\/p>\r\n\r\n\r\n\r\n

\"\"\r\n
Figure1.Effects of NGC on differentiation markers of human normal epidermal keratinocytes (NHEKs).<\/em><\/figcaption>\r\n<\/figure>\r\n\r\n\r\n\r\n

Conlusion<\/strong><\/h2>\r\n\r\n\r\n\r\n

Mild oxidative stimulation of NGCs could lead to healthy skin through their hormesis<\/a> effect on antioxidant activity and barrier functions.<\/p>\r\n\r\n\r\n\r\n

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Figure 3. Expression of HO-1,NQO1 and GSH by Nrf2-Keap1 signal<\/em><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n\r\n\r\n\r\n
\r\n
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Figure3.Multi effect of skin-health by NGCs.<\/em><\/figcaption>\r\n<\/figure>\r\n<\/div>\r\n<\/div>\r\n","protected":false},"excerpt":{"rendered":"

Mediplus Pharma, Inc. (CEO: Kenji Ito, Head Office: Shibuya-ku, Tokyo,JAPAN) made a scientific presentation at the annual meeting of the Society for Investigative Dermatology (May 18-21, 2022, Portland, USA), which is considered the world’s highest-level society in dermatological research. Title\uff1aNovel glycerin compounds improve skin health<\/p>\n","protected":false},"author":1,"featured_media":2151,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[77],"tags":[],"class_list":["post-2173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conferencesexhibitions"],"yoast_head":"\nMediplus Pharma is presenting posters at Society for Investigative Dermatology\uff08SID\uff09annual meeting 2022 - Mediplus Pharma, Inc.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mediplus Pharma is presenting posters at Society for Investigative Dermatology\uff08SID\uff09annual meeting 2022 - Mediplus Pharma, Inc.\" \/>\n<meta property=\"og:description\" content=\"Mediplus Pharma, Inc. (CEO: Kenji Ito, Head Office: Shibuya-ku, Tokyo,JAPAN) made a scientific presentation at the annual meeting of the Society for Investigative Dermatology (May 18-21, 2022, Portland, USA), which is considered the world’s highest-level society in dermatological research. Title\uff1aNovel glycerin compounds improve skin health\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/\" \/>\n<meta property=\"og:site_name\" content=\"Mediplus Pharma, Inc.\" \/>\n<meta property=\"article:published_time\" content=\"2022-05-18T01:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-09T04:25:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/06\/2022logosmall.png\" \/>\n\t<meta property=\"og:image:width\" content=\"480\" \/>\n\t<meta property=\"og:image:height\" content=\"161\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Mediplus Pharma\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/\",\"url\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/\",\"name\":\"Mediplus Pharma is presenting posters at Society for Investigative Dermatology\uff08SID\uff09annual meeting 2022 - Mediplus Pharma, Inc.\",\"isPartOf\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/06\/2022logosmall.png\",\"datePublished\":\"2022-05-18T01:00:00+00:00\",\"dateModified\":\"2025-12-09T04:25:24+00:00\",\"author\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/#\/schema\/person\/6b64defb6ffc8a545a1aa0d1a36a5d9e\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/#primaryimage\",\"url\":\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/06\/2022logosmall.png\",\"contentUrl\":\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/06\/2022logosmall.png\",\"width\":480,\"height\":161,\"caption\":\"sid portland22\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/mediplus-pharma-is-presenting-posters-at-society-for-investigative-dermatology%ef%bc%88sid%ef%bc%89annual-meeting-2022\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u30db\u30fc\u30e0\",\"item\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mediplus Pharma is presenting posters at Society for Investigative Dermatology\uff08SID\uff09annual meeting 2022\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/#website\",\"url\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/\",\"name\":\"Mediplus Pharma, Inc.\",\"description\":\"Passion for Sustainable Future By Novel Glycerin Compounds. 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