{"id":2394,"date":"2002-05-31T15:00:00","date_gmt":"2002-05-31T06:00:00","guid":{"rendered":"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/?p=2394"},"modified":"2025-12-09T13:27:26","modified_gmt":"2025-12-09T04:27:26","slug":"investigation-of-bactericidal-and-fungicidal-effects-of-stabilized-ozone-gel","status":"publish","type":"post","link":"https:\/\/www.mediplus-pharma.co.jp\/en\/investigation-of-bactericidal-and-fungicidal-effects-of-stabilized-ozone-gel\/","title":{"rendered":"Investigation of Bactericidal and Fungicidal Effects of Stabilized Ozone Gel"},"content":{"rendered":"<p>Mediplus Pharma, Inc. (Formerly VMC Corporation) Gotaro Shiota<br \/>\nYoshiaki Maruyama, Kikumi Suzuki<br \/>\nShowa University School of Dentistry, Department of Prosthodontics, Akihiko Shiba<br \/>\nTokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Shiba Kiyoko, Okamura Noboru,<br \/>\nChida Toshio<br \/>\nDivision of Laboratory Medicine, Chiba University Hospital, Asako Kimura<!--more--><\/p>\n<h3>Development Background:<\/h3>\n<p>Disinfection with ozone gas or ozonated water is more useful than conventional disinfectants because it is effective on a wide spectrum of bacteria, yeast, mold, viruses, etc. and does not leave residue, preventing the emergence of resistant strains. However, ozone has a short half-life of less than one hour, which means that ozone must be generally produced where it is used, thus limiting its scope of application.<br \/>\nTo overcome this shortcoming of ozone, we have developed a new ozone compound, stabilized ozone gel, using glycerin as a solvent, which can be stored long-term and has an expanded range of applications.<\/p>\n<h3>Objectives:<\/h3>\n<p>\u30fbInvestigation of the bactericidal and fungicidal effects of stabilized ozone gel (OG) on various microbial species and inhibition of their growth over time.<br \/>\n\u30fbExamination of OG\u2019s sterilization concentration and effects of storage.<\/p>\n<p>Test strains for OG disinfection:<br \/>\nStandard strains<br \/>\nEscherichia coli ATCC25922<br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/pseudomonas-aeruginosa\/\" target=\"_blank\" rel=\"noopener\">Pseudomonas aeruginosa<\/a> ATCC27853<br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/staphylococcus-aureus\/\" target=\"_blank\" rel=\"noopener\">Staphylococcus aureus<\/a> ATCC25923<br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/%e3%82%ab%e3%83%b3%e3%82%b8%e3%83%80%e3%83%bb%e3%82%a2%e3%83%ab%e3%83%93%e3%82%ab%e3%83%b3%e3%82%b9-candida-albicans\/\" target=\"_blank\" rel=\"noopener\">Candida albicans<\/a> IAM4966<\/p>\n<p>Clinical isolates<br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/methicillin-resistant-staphylococcus-aureus\/\" target=\"_blank\" rel=\"noopener\">Methicillin-resistant S. aureus (MRSA)<\/a><br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/staphylococcus-epidermidis\/\" target=\"_blank\" rel=\"noopener\">Staphylococcus epidemidis<\/a><br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/%e8%82%ba%e7%82%8e%e6%a1%bf%e8%8f%8c-klebsiella-pneumoniae\/\" target=\"_blank\" rel=\"noopener\">Klebsiella pneumoniae<\/a><br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/salmonella-enteritidis\/\" target=\"_blank\" rel=\"noopener\">Salmonella enteritidis<\/a><br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/legionella-pneumophila\/\" target=\"_blank\" rel=\"noopener\">Legionella pneumophila<\/a><br \/>\n<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/bacillus-subtilis\/\" target=\"_blank\" rel=\"noopener\">Bacillus subtilis<\/a><\/p>\n<h3>Results:<\/h3>\n<p>We developed an effective disinfectant OG that can be stored.<br \/>\nThe<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/en\/oxidation-2\/\" target=\"_blank\" rel=\"noopener\"> oxidation<\/a> power of purified OG was extremely strong, and its bactericidal and fungicidal effects remained effective after dilution.<br \/>\nSimilar to conventional ozonated water, it effectively eliminated a wide spectrum of microorganisms, and did so in a relatively short time.<\/p>\n<h3>Future outlook:<\/h3>\n<p>The applications of OG which have been limited thus far, will be expanded with this storable form. Furthermore, applications that take advantage of the properties of the solvent glycerin (hydrosolubility and moisture-retention) will also be explored for its potential as a treatment for pressure sores, as a mouthwash, or as a hand disinfectant.<\/p>\n<p>Bactericidal and fungicidal effects of ozone gel<\/p>\n<p>Methods: To determine the bactericidal and fungicidal effects of OG, Okamura\u2019s semi-quantitative viable count method using a 96-well plate was used. First, about 108 CFU\/ml of the microbial solution with 10 times the amount of OG are mixed, and after exposure time, sodium thiosulfate is mixed to stop the reaction, after which 10 \u00b5l of that admixture is placed in the 1st column prepared with the culture medium to make a 10-fold dilution series up to 12 columns sequentially. Then, the culture is incubated overnight at 37\u00b0C to observe how many columns have developed the bacterial and fungal growth, and calculate the count from the dilution ratio to take the semi-quantitative measurement.<br \/>\nWith this measurement method, the limit of detection for the viable count is \u201c102 CFU\/ml or less,\u201d which is not very precise. However, this method was selected aiming to present an introductory overview of the bactericidal and fungicidal effects of the novel compound OG.<\/p>\n<h3>\u30fbEffects of storage on the bactericidal effect of ozone gel<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2414 size-full\" src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/12\/1.jpeg\" alt=\"\" width=\"720\" height=\"540\" \/><\/p>\n<p>The results for S. aureus and E. coli are shown on the left and right graphs. The vertical axis shows the viable count, and the horizontal axis represents the exposure time. Compared to the controls (sterilized water and glycerin), newly purified OG and OG stored for 2 months after purification both demonstrated strong bactericidal effects that reduced the viable count below the limit of detection.<\/p>\n<h3>Bactericidal effects of ozone gel by concentration<\/h3>\n<p>\u30fb Undiluted ozone gel<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2416 aligncenter\" src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/12\/2.jpeg\" alt=\"\" width=\"720\" height=\"540\" \/>The bactericidal power of undiluted OG was investigated in 6 species shown in the Table. With the exception of B. subtilis, a significant bactericidal effect was observed immediately after contact with OG until the viable count was below the limit of detection.<br \/>\nThe oxidizing power of undiluted OG was several hundred units, equivalent to several hundred ppm in ozone concentration. This exceeded the concentration of ozonated water, which is used as a disinfectant, so we diluted OG with glycerin to investigate its bactericidal effects at concentrations comparable to existing products.<\/p>\n<h3>\u30fbBactericidal and fungicidal effects of 100 ppm OG<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2418 size-full\" src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/12\/3.jpeg\" alt=\"\" width=\"720\" height=\"540\" \/><\/p>\n<p>The bactericidal and fungicidal power of 100 ppm ozone gel was investigated in 6 species.<br \/>\nWe observed the bactericidal and fungicidal effect over time up to an exposure time of 120 minutes. The results are shown on the slide. With the exception of B. subtilis, all other species reached the limit of detection within 1 min.<\/p>\n<h3>\u30fbBactericidal and fungicidal effect of 10ppm ozone gel<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2420 aligncenter\" src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2022\/12\/4.jpeg\" alt=\"\" width=\"720\" height=\"540\" \/><\/p>\n<p>The bactericidal and fungicidal power of 10 ppm ozone gel was investigated in 6 species.<br \/>\nWe observed the bactericidal and fungicidal effect of OG over an exposure time upto 360 minutes. The results are shown on the slide. C. albicans, E. coli, P.aeruginosa, K. pneumoniae, and S. epidemidis reached the limit of detection at 1, 30, 30, 120, and 180 min, respectively.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mediplus Pharma, Inc. (Formerly VMC Corporation) Gotaro Shiota Yoshiaki Maruyama, Kikumi Suzuki Showa University School of Dentistry, Department of Prosthodontics, Akihiko Shiba Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Shiba Kiyoko, Okamura Noboru, Chida Toshio Division of Laboratory Medicine, Chiba University Hospital, Asako Kimura<\/p>\n","protected":false},"author":6,"featured_media":2078,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[130],"tags":[],"class_list":["post-2394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academic-paper-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Investigation of Bactericidal and Fungicidal Effects of Stabilized Ozone Gel - Mediplus Pharma, Inc.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mediplus-pharma.co.jp\/en\/investigation-of-bactericidal-and-fungicidal-effects-of-stabilized-ozone-gel\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigation of Bactericidal and Fungicidal Effects of Stabilized Ozone Gel - Mediplus Pharma, Inc.\" \/>\n<meta property=\"og:description\" content=\"Mediplus Pharma, Inc. 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