{"id":3324,"date":"2024-05-15T09:21:11","date_gmt":"2024-05-15T00:21:11","guid":{"rendered":"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/?p=3324"},"modified":"2025-11-28T11:19:20","modified_gmt":"2025-11-28T02:19:20","slug":"patent","status":"publish","type":"post","link":"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/","title":{"rendered":"Patents and Publications"},"content":{"rendered":"\r\n<h2 class=\"wp-block-heading\">PATENT<\/h2>\r\n\r\n\r\n\r\n<p>In 2001, our company pioneered the world\u2019s first patented ingredient, Ozonized Glycerin, and has been exploring its potential ever since. After obtaining patents in 2004, over 100 papers have been published in academic journals and presented at conferences. Our research was recently featured on the \u201cJournal of Cosmetic Dermatology\u201d cover in 2022. Looking ahead, we\u2019re committed to continuing our research and development as a trailblazing company in Ozonized Glycerin, striving to innovate superior manufacturing methods and applications.<br \/><br \/>Currently, we\u2019ve secured four patents and numerous patent applications pending for further inventions and improvements in Japan and overseas. Our focus remains on strengthening the protection of our rights through patent registration.<br \/><br \/>4 registered patents: 6431251, 6671832, 7534001, 7575652<br \/>4 PCT applications filed: PCT\/JP2022\/031273, PCT\/JP2024\/29136, PCT\/JP2024\/026036, PCT\/JP2024\/21035<br \/>Three patent applications have been filed: 2024-204694, 2024-117854, 2024-89472<\/p>\r\n\r\n\r\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\r\n\r\n\r\n<h2 class=\"wp-block-heading\">PUBLICATIONS<\/h2>\r\n\r\n\r\n\r\n<figure class=\"wp-block-table is-style-stripes\">\r\n<table>\r\n<thead>\r\n<tr>\r\n<th>Title<\/th>\r\n<th>Journal<\/th>\r\n<th>Year<\/th>\r\n<\/tr>\r\n<\/thead>\r\n<tbody>\r\n<tr>\r\n<td>The bactericidal effect of ozone gel<\/td>\r\n<td>Showa Univ J Med Sci<\/td>\r\n<td>2004<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Application of ozone gel to the field of endodontics: A study of its bactericidal effect and cytotoxicity.<\/td>\r\n<td>J Japan Endodontic Association,<\/td>\r\n<td>2012<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Antimicrobial effects of ozone gel on caries-causing bacteria.<\/td>\r\n<td>Jpn J Conservative Dentistry,<\/td>\r\n<td>2013<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Effects of ozone gel on oral bacteria and its effects on human gingival and periodontal ligament fibroblasts.<\/td>\r\n<td>Jpn J Conservative Dentistry,<\/td>\r\n<td>2014<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria.<\/td>\r\n<td>Journal of Hard Tissue Biology 23[4] (2014)<\/td>\r\n<td>2014<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>The Effect of Ozone on Collagen Type-1 and Inflammatory Cytokine Production in Human Gingival Fibroblasts.<\/td>\r\n<td>Dentistry 2015<\/td>\r\n<td>2015<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>The E\uff6c\\ect of Ozone Gel on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2.<\/td>\r\n<td>Journal of Hard Tissue Biology 27[3] (2018)<\/td>\r\n<td>2018<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Inactivation of SARS-CoV-2 by Ozonated Glycerol<\/td>\r\n<td>Food and Environmental Virology (2021)<\/td>\r\n<td>2021<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Ozonized glycerin (OG)-based cosmetic products lighten age spots on human facial skin.<\/td>\r\n<td>J Cosmet Dermatol. 2022<\/td>\r\n<td>2022<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Comparative Study of Ozonated Glycerol and Macrogol Ointment on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2.<\/td>\r\n<td>Materials 2023<\/td>\r\n<td>2023<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/figure>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>PATENT In 2001, our company pioneered the world\u2019s first patented ingredient, Ozonized Glycerin, and has been exploring its potential ever since. After obtaining patents in 2004, over 100 papers have been published in academic journals and presented at conferences. Our research was recently featured on the \u201cJournal of Cosmetic Dermatology\u201d cover in 2022. Looking ahead, we\u2019re committed to continuing our [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3368,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[129,126],"tags":[],"class_list":["post-3324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-patents-and-publications","category-technology-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Patents and Publications - Mediplus Pharma, Inc.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Patents and Publications - Mediplus Pharma, Inc.\" \/>\n<meta property=\"og:description\" content=\"PATENT In 2001, our company pioneered the world\u2019s first patented ingredient, Ozonized Glycerin, and has been exploring its potential ever since. After obtaining patents in 2004, over 100 papers have been published in academic journals and presented at conferences. Our research was recently featured on the \u201cJournal of Cosmetic Dermatology\u201d cover in 2022. Looking ahead, we\u2019re committed to continuing our [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/\" \/>\n<meta property=\"og:site_name\" content=\"Mediplus Pharma, Inc.\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-15T00:21:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-28T02:19:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/05\/ozonation2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2250\" \/>\n\t<meta property=\"og:image:height\" content=\"1425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Mediplus Pharma\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/\",\"url\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/\",\"name\":\"Patents and Publications - Mediplus Pharma, Inc.\",\"isPartOf\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/05\/ozonation2.png\",\"datePublished\":\"2024-05-15T00:21:11+00:00\",\"dateModified\":\"2025-11-28T02:19:20+00:00\",\"author\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/#\/schema\/person\/6b64defb6ffc8a545a1aa0d1a36a5d9e\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/#primaryimage\",\"url\":\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/05\/ozonation2.png\",\"contentUrl\":\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/05\/ozonation2.png\",\"width\":2250,\"height\":1425},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/patent\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u30db\u30fc\u30e0\",\"item\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Patents and Publications\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/#website\",\"url\":\"https:\/\/www.mediplus-pharma.co.jp\/en\/\",\"name\":\"Mediplus Pharma, Inc.\",\"description\":\"Passion for Sustainable Future By Novel Glycerin Compounds. 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