{"id":5704,"date":"2025-12-08T14:07:25","date_gmt":"2025-12-08T05:07:25","guid":{"rendered":"https:\/\/www.mediplus-pharma.co.jp\/?p=5704"},"modified":"2026-01-30T09:32:23","modified_gmt":"2026-01-30T00:32:23","slug":"ingredients-and-evidence","status":"publish","type":"post","link":"https:\/\/www.mediplus-pharma.co.jp\/en\/ingredients-and-evidence\/","title":{"rendered":"Ingredients AND Evidence"},"content":{"rendered":"\n<style type=\"text\/css\" id=\"style-css-av-mhcpki4l-80386f4b07a62975f2c8c2d5766a330b\">\n#top .av-special-heading.av-mhcpki4l-80386f4b07a62975f2c8c2d5766a330b{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcpki4l-80386f4b07a62975f2c8c2d5766a330b av-special-heading-h1 blockquote modern-quote modern-centered  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Ingredients AND Evidence<\/h1><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6\">\n.hr.av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6 .hr-inner{\nwidth:30%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6 hr-custom  avia-builder-el-1  el_after_av_heading  el_before_av_heading  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bf' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcpmnn7-41c2f671dcf7c5993da730aab40eda3e\">\n#top .av-special-heading.av-mhcpmnn7-41c2f671dcf7c5993da730aab40eda3e{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcpmnn7-41c2f671dcf7c5993da730aab40eda3e av-special-heading-h2 blockquote modern-quote  avia-builder-el-2  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >What Is Ozonized Glycerin (OG)?<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Obtained patents for the manufacturing method, applications, and formulations of a novel ozonized compound discovered through the reaction of glycerin and ozone.<\/p>\n<ul>\n<li>Viscosity: Comparable to glycerin or slightly lower, yet higher than BG.<\/li>\n<li>Texture: Slightly less tacky than glycerin.<\/li>\n<li>Stability: Ozonized glycerin is odorless and colorless, with high stability against temperature fluctuations.<\/li>\n<\/ul>\n<\/div><\/section>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\"><span style=\"font-size: 150%;\"><strong><sub>Ozone (O\u2083) is formed when one additional oxygen atom attaches to molecular oxygen (O\u2082).<br \/>\n<\/sub><\/strong><\/span><span style=\"font-size: 150%;\"><strong>O<sub>2<\/sub>+O=O<sub>3<\/sub><\/strong><\/span><\/p>\n<\/div><\/section>\n<div  class='hr av-cgavka-b6f48ced3b7dc2a5a20733d22845e5b2 hr-default  avia-builder-el-5  el_after_av_textblock  el_before_av_heading  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcr4pei-5b684de3c7b8fd8729d34a6e9853e386\">\n#top .av-special-heading.av-mhcr4pei-5b684de3c7b8fd8729d34a6e9853e386{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcr4pei-5b684de3c7b8fd8729d34a6e9853e386 av-special-heading-h2 blockquote modern-quote  avia-builder-el-6  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Functional Benefits (Restores the Skin Barrier)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Enhances the production of filaggrin, which becomes NMF; ceramides, the key intercellular lipids; and <a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/%e3%82%a4%e3%83%b3%e3%83%9c%e3%83%ab%e3%82%af%e3%83%aa%e3%83%b3%ef%bc%88inv%ef%bc%89involucrin\/\">involucrin<\/a>, the extracellular envelope protein \uff08<span style=\"font-weight: 400;\">in vitro<\/span>\uff09<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-cxnga-c226c4c650f58cfd51d6055655de805b\">\n#top .flex_column.av-cxnga-c226c4c650f58cfd51d6055655de805b{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-cxnga-c226c4c650f58cfd51d6055655de805b av_one_half  avia-builder-el-8  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-mhcr7lzb-27bd6a49eba8e79aa40b9938b6685d82\">\n.avia-image-container.av-mhcr7lzb-27bd6a49eba8e79aa40b9938b6685d82 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcr7lzb-27bd6a49eba8e79aa40b9938b6685d82 av-styling- avia-align-center  avia-builder-el-9  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1030x794.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-705x544.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin.jpg 1729w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" class='avia_image' ><img decoding=\"async\" width=\"1729\" height=\"1333\" class='wp-image-3271 avia-img-lazy-loading-not-3271 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin.jpg\" alt='' title='graph'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin.jpg 1729w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-1_Pro-filaggrin-705x544.jpg 705w\" sizes=\"(max-width: 1729px) 100vw, 1729px\" \/><\/a><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-1vgygq-cf8542f16203007680f25b20a88edf49\">\n#top .flex_column.av-1vgygq-cf8542f16203007680f25b20a88edf49{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-1vgygq-cf8542f16203007680f25b20a88edf49 av_one_half  avia-builder-el-10  el_after_av_one_half  el_before_av_textblock  flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-mhcr83lu-ca0774e0a8f3dd28a5fc51033eeceee4\">\n.avia-image-container.av-mhcr83lu-ca0774e0a8f3dd28a5fc51033eeceee4 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcr83lu-ca0774e0a8f3dd28a5fc51033eeceee4 av-styling- avia-align-center  avia-builder-el-11  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1030x794.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-705x544.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2.jpg 1729w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" class='avia_image' ><img decoding=\"async\" width=\"1729\" height=\"1333\" class='wp-image-3273 avia-img-lazy-loading-not-3273 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2.jpg\" alt='' title='graph'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2.jpg 1729w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/1-2_Serine_palmitoyltransferaseSPTLC2-705x544.jpg 705w\" sizes=\"(max-width: 1729px) 100vw, 1729px\" \/><\/a><\/div><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Compared with glycerin, ozonated glycerin was shown to increase filaggrin (left) and ceramides (right).<br \/>\nIt has also been confirmed to activate multiple other factors, including<a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/%e3%82%a4%e3%83%b3%e3%83%9c%e3%83%ab%e3%82%af%e3%83%aa%e3%83%b3%ef%bc%88inv%ef%bc%89involucrin\/\"> involucrin<\/a>.<\/p>\n<\/div><\/section>\n<div  class='hr av-b7nd6y-df29065eef35576a3d85ed60f8ac3743 hr-default  avia-builder-el-13  el_after_av_textblock  el_before_av_one_full  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-9r72y-dff77eb5f575739d6a22cda4f5dcfe57\">\n#top .flex_column.av-9r72y-dff77eb5f575739d6a22cda4f5dcfe57{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-9r72y-dff77eb5f575739d6a22cda4f5dcfe57 av_one_full  avia-builder-el-14  el_after_av_hr  el_before_av_hr  first flex_column_div av-zero-column-padding '   ><p>\n<style type=\"text\/css\" id=\"style-css-av-mhcrc586-c1af2e35cd1bf78b36b027cc8487b1e7\">\n#top .av-special-heading.av-mhcrc586-c1af2e35cd1bf78b36b027cc8487b1e7{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcrc586-c1af2e35cd1bf78b36b027cc8487b1e7 av-special-heading-h2 blockquote modern-quote  avia-builder-el-15  el_before_av_textblock  avia-builder-el-first  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Functional Benefits (Enhances Autophagy Activity)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Activates autophagy (LC3-II), improving the quality of cellular renewal (differentiation) and promoting the degradation of melanosomes (<em><span style=\"font-weight: 400;\">in vitro<\/span><span style=\"font-weight: 400;\">\uff09.<\/span><\/em><\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcrfqgj-3cd2c69d309f184245ea8576aedc0952\">\n.avia-image-container.av-mhcrfqgj-3cd2c69d309f184245ea8576aedc0952 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcrfqgj-3cd2c69d309f184245ea8576aedc0952 av-styling- avia-align-center  avia-builder-el-17  el_after_av_textblock  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-1030x873.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-1030x873.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-300x254.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-768x651.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-705x598.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en.jpg 1229w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" class='avia_image' ><img decoding=\"async\" width=\"1229\" height=\"1042\" class='wp-image-3279 avia-img-lazy-loading-not-3279 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en.jpg\" alt='' title='autophagy-activity'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en.jpg 1229w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-300x254.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-1030x873.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-768x651.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/autophagy-activity-en-705x598.jpg 705w\" sizes=\"(max-width: 1229px) 100vw, 1229px\" \/><\/a><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"text-align: center;\">The green-stained areas indicate autophagy (LC3-II).<\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Topical application of ozonized glycerin was found to enhance autophagy activity in skin cells.<\/p>\n<\/div><\/section><\/p><\/div>\n<div  class='hr av-8x1oq2-f68dc463ac46f8a786f5d5bf3d0c706c hr-default  avia-builder-el-20  el_after_av_one_full  el_before_av_heading  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcrwlgr-f8721d3448cad8abfe34ab7f0684d54e\">\n#top .av-special-heading.av-mhcrwlgr-f8721d3448cad8abfe34ab7f0684d54e{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcrwlgr-f8721d3448cad8abfe34ab7f0684d54e av-special-heading-h2 blockquote modern-quote  avia-builder-el-21  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Functional Benefits (Anti-Inflammatory and Antioxidant Effects)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><span style=\"font-weight: 400;\"><em>Activates Nrf2, enhancing the production of antioxidant molecules such as glutathione and HO-1 (heme oxygenase), which support skin homeostasis and strengthen the skin\u2019s ability to resist oxidative stress and inflammation\uff08<\/em><\/span><em><span style=\"font-weight: 400;\">in vitro<\/span><span style=\"font-weight: 400;\">\uff09.<\/span><\/em><\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-3mfjoq-bbea8b94b2d3a02eba3c89248c071a57\">\n#top .flex_column.av-3mfjoq-bbea8b94b2d3a02eba3c89248c071a57{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-3mfjoq-bbea8b94b2d3a02eba3c89248c071a57 av_one_half  avia-builder-el-23  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-mhcrz643-b4bda825d5c8ab04c2c6fbaf1d587a28\">\n.avia-image-container.av-mhcrz643-b4bda825d5c8ab04c2c6fbaf1d587a28 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcrz643-b4bda825d5c8ab04c2c6fbaf1d587a28 av-styling- avia-align-center  avia-builder-el-24  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1030x794.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-705x544.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h.jpg 1729w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" class='avia_image' ><img decoding=\"async\" width=\"1729\" height=\"1333\" class='wp-image-3275 avia-img-lazy-loading-not-3275 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h.jpg\" alt='' title='graph'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h.jpg 1729w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-1_24h-705x544.jpg 705w\" sizes=\"(max-width: 1729px) 100vw, 1729px\" \/><\/a><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-b2cm2-71fca50131701902b2cc02a43c6f5f35\">\n#top .flex_column.av-b2cm2-71fca50131701902b2cc02a43c6f5f35{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-b2cm2-71fca50131701902b2cc02a43c6f5f35 av_one_half  avia-builder-el-25  el_after_av_one_half  el_before_av_textblock  flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-mhcrzjfj-9fecc45d252418212b14555ed0a25f14\">\n.avia-image-container.av-mhcrzjfj-9fecc45d252418212b14555ed0a25f14 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcrzjfj-9fecc45d252418212b14555ed0a25f14 av-styling- avia-align-center  avia-builder-el-26  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1030x794.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-705x544.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1.jpg 1729w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" class='avia_image' ><img decoding=\"async\" width=\"1729\" height=\"1333\" class='wp-image-3277 avia-img-lazy-loading-not-3277 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1.jpg\" alt='' title='graph'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1.jpg 1729w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-300x231.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1030x794.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-768x592.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1536x1184.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-1500x1156.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2024\/04\/2-2_HO-1-705x544.jpg 705w\" sizes=\"(max-width: 1729px) 100vw, 1729px\" \/><\/a><\/div><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Compared with glycerin, ozonized glycerin was shown to increase glutathione (left) and HO-1 (right).<\/p>\n<\/div><\/section>\n<div  class='hr av-6z8tre-93288071c7ae52ae22ed4414117d37d8 hr-default  avia-builder-el-28  el_after_av_textblock  el_before_av_heading  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcsmiz7-03e69455366f763ed423064c01418105\">\n#top .av-special-heading.av-mhcsmiz7-03e69455366f763ed423064c01418105{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcsmiz7-03e69455366f763ed423064c01418105 av-special-heading-h2 blockquote modern-quote  avia-builder-el-29  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Functional Benefits (Human Use Study)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Compared with well-known moisturizing ingredients such as hyaluronic acid (HA) and ceramides (CERA), ozonized glycerin demonstrates approximately 3.5 times the moisture-retention capacity of HA and about 2.4 times the barrier-support index of CERA.<br \/>\nConventional moisturizing ingredients have largely focused on either supplying moisture or reinforcing the barrier. Ozonized glycerin works directly on the molecular environment of the stratum corneum, providing high-level support for both moisture retention and barrier function.<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-4pzdei-23c6787932a8bcecc8ef667650e865a8\">\n#top .flex_column.av-4pzdei-23c6787932a8bcecc8ef667650e865a8{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-4pzdei-23c6787932a8bcecc8ef667650e865a8 av_one_half  avia-builder-el-31  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'   ><p>\n<style type=\"text\/css\" id=\"style-css-av-mhd2v8sm-f332dce5f425e5c32a1abe0469c2d19e\">\n#top .av-special-heading.av-mhd2v8sm-f332dce5f425e5c32a1abe0469c2d19e{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhd2v8sm-f332dce5f425e5c32a1abe0469c2d19e av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-32  el_before_av_image  avia-builder-el-first  '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >3.5 times the moisture-retention capacity of hyaluronic acid.<\/h3><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcsqena-150976792c866de2ab77dd94e3033071\">\n.avia-image-container.av-mhcsqena-150976792c866de2ab77dd94e3033071 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcsqena-150976792c866de2ab77dd94e3033071 av-styling- avia-align-center  avia-builder-el-33  el_after_av_heading  avia-builder-el-last  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en.jpg 960w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en-300x181.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en-768x463.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en-705x425.jpg 705w\" data-sizes=\"(max-width: 960px) 100vw, 960px\" class='avia_image' ><img decoding=\"async\" width=\"960\" height=\"579\" class='wp-image-5722 avia-img-lazy-loading-not-5722 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en.jpg\" alt='' title='hosui_en'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en.jpg 960w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en-300x181.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en-768x463.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/hosui_en-705x425.jpg 705w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><\/a><\/div><\/div><\/div><\/p><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-2ulbfu-3af7d48751141b6f8686e42c845dc940\">\n#top .flex_column.av-2ulbfu-3af7d48751141b6f8686e42c845dc940{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-2ulbfu-3af7d48751141b6f8686e42c845dc940 av_one_half  avia-builder-el-34  el_after_av_one_half  el_before_av_textblock  flex_column_div av-zero-column-padding column-top-margin'   ><p>\n<style type=\"text\/css\" id=\"style-css-av-mhd2wau6-0031896915a69fc51b571df9273f31ab\">\n#top .av-special-heading.av-mhd2wau6-0031896915a69fc51b571df9273f31ab{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhd2wau6-0031896915a69fc51b571df9273f31ab av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-35  el_before_av_image  avia-builder-el-first  '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >2.4 times the skin-barrier support of ceramides.<\/h3><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcsr2xc-2dbe06ea373f7251bcc467ff8a065e0b\">\n.avia-image-container.av-mhcsr2xc-2dbe06ea373f7251bcc467ff8a065e0b .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhcsr2xc-2dbe06ea373f7251bcc467ff8a065e0b av-styling- avia-align-center  avia-builder-el-36  el_after_av_heading  avia-builder-el-last  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en.png\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en.png 920w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en-300x181.png 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en-768x462.png 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en-705x425.png 705w\" data-sizes=\"(max-width: 920px) 100vw, 920px\" class='avia_image' ><img decoding=\"async\" width=\"920\" height=\"554\" class='wp-image-5713 avia-img-lazy-loading-not-5713 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en.png\" alt='' title='ceramide_en'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en.png 920w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en-300x181.png 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en-768x462.png 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/ceramide_en-705x425.png 705w\" sizes=\"(max-width: 920px) 100vw, 920px\" \/><\/a><\/div><\/div><\/div><\/p><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><span style=\"font-size: 80%;\">\u25aa\ufe0fN = 7 (men and women in their 20s\u201350s), conducted in January 2025<br \/>\n\u25aa\ufe0fBulk: Carbomer gel containing each ingredient<br \/>\n\u25aa\ufe0fTest area: Forearm<br \/>\n\u25aa\ufe0fMeasurement devices: Corneometer, Tewameter<\/span><\/p>\n<\/div><\/section>\n<div  class='hr av-5rfysa-8ba06f51d3d3d7cc6bfe336ee6a7d840 hr-default  avia-builder-el-38  el_after_av_textblock  el_before_av_heading  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhd01zdg-b4114c4c7d299200be1f5adfae1f4003\">\n#top .av-special-heading.av-mhd01zdg-b4114c4c7d299200be1f5adfae1f4003{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhd01zdg-b4114c4c7d299200be1f5adfae1f4003 av-special-heading-h2 blockquote modern-quote  avia-builder-el-39  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Functional Benefits (Penetration Study)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>The penetration study shows that OG distributes more uniformly and evenly throughout the cross-section.<\/p>\n<p>OG enhances the uniform penetration of oil-soluble ingredients, which can improve both the spreadability and the overall performance of emulsions, creams, and serums.<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-41o8ru-ce30762b418d9a4941e3779d54d45c08\">\n#top .flex_column.av-41o8ru-ce30762b418d9a4941e3779d54d45c08{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-41o8ru-ce30762b418d9a4941e3779d54d45c08 av_one_half  avia-builder-el-41  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'   ><p>\n<style type=\"text\/css\" id=\"style-css-av-mhd316cx-291cec97163f4724f6242c46835de9e1\">\n#top .av-special-heading.av-mhd316cx-291cec97163f4724f6242c46835de9e1{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhd316cx-291cec97163f4724f6242c46835de9e1 av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-42  el_before_av_image  avia-builder-el-first  '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Appearance after 5 minutes<\/h3><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-mhd09lvy-90fd1a238a0b8542a53e508e59d6f0b4\">\n.avia-image-container.av-mhd09lvy-90fd1a238a0b8542a53e508e59d6f0b4 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhd09lvy-90fd1a238a0b8542a53e508e59d6f0b4 av-styling- avia-align-center  avia-builder-el-43  el_after_av_heading  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELen.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELen.jpg 516w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELen-300x181.jpg 300w\" data-sizes=\"(max-width: 516px) 100vw, 516px\" class='avia_image' ><img decoding=\"async\" width=\"516\" height=\"312\" class='wp-image-5724 avia-img-lazy-loading-not-5724 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELen.jpg\" alt='' title='5minGELen'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELen.jpg 516w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELen-300x181.jpg 300w\" sizes=\"(max-width: 516px) 100vw, 516px\" \/><\/a><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>A sponge was soaked in 5% solutions of both glycerin and OG.<\/p>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-2wlz6i-cfd6cb8ea86c6277ecce6069d1d6cd00\">\n#top .flex_column.av-2wlz6i-cfd6cb8ea86c6277ecce6069d1d6cd00{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-2wlz6i-cfd6cb8ea86c6277ecce6069d1d6cd00 av_one_half  avia-builder-el-45  el_after_av_one_half  el_before_av_textblock  flex_column_div av-zero-column-padding column-top-margin'   ><p>\n<style type=\"text\/css\" id=\"style-css-av-mhd31lwc-db58c0cb981b223c8639b6bcf928f064\">\n#top .av-special-heading.av-mhd31lwc-db58c0cb981b223c8639b6bcf928f064{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhd31lwc-db58c0cb981b223c8639b6bcf928f064 av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-46  el_before_av_image  avia-builder-el-first  '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Cross-section after 5 minutes<\/h3><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-mhd0a31m-114001026e877b5b52667094c2d25f00\">\n.avia-image-container.av-mhd0a31m-114001026e877b5b52667094c2d25f00 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhd0a31m-114001026e877b5b52667094c2d25f00 av-styling- avia-align-center  avia-builder-el-47  el_after_av_heading  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELharf_en.jpg\" data-srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELharf_en.jpg 516w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELharf_en-300x181.jpg 300w\" data-sizes=\"(max-width: 516px) 100vw, 516px\" class='avia_image' ><img decoding=\"async\" width=\"516\" height=\"312\" class='wp-image-5726 avia-img-lazy-loading-not-5726 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELharf_en.jpg\" alt='' title='5minGELharf_en'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELharf_en.jpg 516w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/5minGELharf_en-300x181.jpg 300w\" sizes=\"(max-width: 516px) 100vw, 516px\" \/><\/a><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>The 5% OG solution on the right shows more uniform penetration.<\/p>\n<\/div><\/section><\/p><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><span style=\"font-size: 80%;\">Method<br \/>\n\u2460A gel containing 5% OG or glycerin and 2% squalane was dyed blue, and a melanin sponge was placed on top to observe penetration.<br \/>\n\u2461After 5 minutes, the sponge was removed, cut in half, and the cross-section was examined.<\/span><\/p>\n<\/div><\/section>\n<div  class='hr av-4xu2ve-0b6b3642d14a3f7dc777fd29fb9bcc4d hr-default  avia-builder-el-50  el_after_av_textblock  el_before_av_heading  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhd16b66-04206bf8841259da62038ffc50b5c800\">\n#top .av-special-heading.av-mhd16b66-04206bf8841259da62038ffc50b5c800{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhd16b66-04206bf8841259da62038ffc50b5c800 av-special-heading-h2 blockquote modern-quote  avia-builder-el-51  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Functional Benefits (Preservative Efficacy Test)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Ozonated glycerin demonstrates strong preservative efficacy.<br \/>\nWhen five standard strains were intentionally inoculated into ozonated glycerin, the microbial count dropped to below 100 CFU\/g within one day and showed no regrowth through day 28 of incubation.<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-mhd17t3q-6063182279ebbe9001b6a4d49974ae2d\">\n.avia-image-container.av-mhd17t3q-6063182279ebbe9001b6a4d49974ae2d .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhd17t3q-6063182279ebbe9001b6a4d49974ae2d av-styling- avia-align-center  avia-builder-el-53  el_after_av_textblock  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-5729 avia-img-lazy-loading-not-5729 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/Sterilization_en.png\" alt='' title='Sterilization_en'  height=\"358\" width=\"901\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/Sterilization_en.png 901w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/Sterilization_en-300x119.png 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/Sterilization_en-768x305.png 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2025\/11\/Sterilization_en-705x280.png 705w\" sizes=\"(max-width: 901px) 100vw, 901px\" \/><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><span style=\"font-size: 80%;\">ChatGPT:<br \/>\n\u25aa\ufe0fTest period: June 2024<br \/>\n\u25aa\ufe0fTest facility: Eisei Microbial Research Center Co., Ltd.<br \/>\nTest conducted in accordance with ISO 11903<\/span><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[],"class_list":["post-5704","post","type-post","status-publish","format-standard","hentry","category-ingredients"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ingredients AND Evidence - Mediplus Pharma, Inc.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mediplus-pharma.co.jp\/en\/ingredients-and-evidence\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ingredients AND Evidence - Mediplus Pharma, 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