{"id":6148,"date":"2026-10-01T13:26:16","date_gmt":"2026-10-01T04:26:16","guid":{"rendered":"https:\/\/www.mediplus-pharma.co.jp\/?p=6148"},"modified":"2026-10-01T14:47:31","modified_gmt":"2026-10-01T05:47:31","slug":"ingredients-and-evidence-2","status":"publish","type":"post","link":"https:\/\/www.mediplus-pharma.co.jp\/en\/ingredients-and-evidence-2\/","title":{"rendered":"Ingredients AND Evidence"},"content":{"rendered":"\n<style type=\"text\/css\" id=\"style-css-av-mhcpki4l-80386f4b07a62975f2c8c2d5766a330b\">\n#top .av-special-heading.av-mhcpki4l-80386f4b07a62975f2c8c2d5766a330b{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcpki4l-80386f4b07a62975f2c8c2d5766a330b av-special-heading-h1 blockquote modern-quote modern-centered  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Ingredients AND Evidence<\/h1><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6\">\n.hr.av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6 .hr-inner{\nwidth:30%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-mhcplg70-cfe951ddad8d3c112a894d4098a90bc6 hr-custom  avia-builder-el-1  el_after_av_heading  el_before_av_heading  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bf' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-mhcpmnn7-7b65ba9f671c6caaafeea6b155c9542f\">\n#top .av-special-heading.av-mhcpmnn7-7b65ba9f671c6caaafeea6b155c9542f{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-mhcpmnn7-7b65ba9f671c6caaafeea6b155c9542f av-special-heading-h2 blockquote modern-quote  avia-builder-el-2  el_after_av_hr  el_before_av_textblock  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >What\u2019s Ozonated Functional Complex (OFC)<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p class=\"p1\" style=\"text-align: left;\">Ozonated Functional Complex (OFC) isa functional complex created through our proprietary ozonation technology.<\/p>\n<p class=\"p1\" style=\"text-align: left;\">Designed with a focus on affinity with the stratum corneum and oxygen signaling, OFC takes a multifaceted approach to multiple skin parameters associated with hydration,barrier function, and skin irritation.<\/p>\n<p class=\"p1\" style=\"text-align: left;\">It does more than simply retain moisture like hyaluronic acid, and more than merely replenish barrier components like ceramides.<\/p>\n<p class=\"p1\" style=\"text-align: left;\">OFC is a next-generation active ingredient for barrier care,designed to support the skin\u2019s intrinsic ability to retain moisture and protect itself from external environmental stressors.<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-cgavka-30ffcf25508b02dedbd96e46ead0b45e\">\n.hr.av-cgavka-30ffcf25508b02dedbd96e46ead0b45e{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-cgavka-30ffcf25508b02dedbd96e46ead0b45e .hr-inner{\nwidth:50%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-cgavka-30ffcf25508b02dedbd96e46ead0b45e hr-custom  avia-builder-el-4  el_after_av_textblock  el_before_av_textblock  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bd' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h2 style=\"text-align: center;\">Mechanism of Action<\/h2>\n<h3 style=\"text-align: center;\">Awakening the Skin Through Oxygen Signaling<\/h3>\n<p class=\"p1\" style=\"text-align: center;\">OFC awakens three key functions of the skin.<\/p>\n<p class=\"p2\" style=\"text-align: center;\">\u2460 Barrier Regeneration<br \/>\nRestoration of barrier components such as ceramides<br \/>\n\u2461 Cellular Renewal<br \/>\nActivation of cellular function through autophagy<br \/>\n\u2462 Anti-inflammatory &amp; Antioxidant Defense<br \/>\nActivation of the skin\u2019s protective functions through Nrf2<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-mu3mtkst-a1d37043f32d5501a988c5c074be61ee\">\n.avia-image-container.av-mu3mtkst-a1d37043f32d5501a988c5c074be61ee .av-caption-image-overlay-bg{\nopacity:0.4;\n}\n.avia-image-container.av-mu3mtkst-a1d37043f32d5501a988c5c074be61ee .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mu3mtkst-a1d37043f32d5501a988c5c074be61ee av-styling- avia-align-center  avia-builder-el-6  el_after_av_textblock  el_before_av_hr  noHover av-overlay-hover-deactivate '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><div class='av-image-caption-overlay'><div class='av-caption-image-overlay-bg'><\/div><div class='av-image-caption-overlay-position'><div class='av-image-caption-overlay-center'><\/div><\/div><\/div><img decoding=\"async\" class='wp-image-6153 avia-img-lazy-loading-not-6153 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/09\/skin.jpg\" alt='' title='Screenshot'  height=\"545\" width=\"962\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/09\/skin.jpg 962w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/09\/skin-300x170.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/09\/skin-768x435.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/09\/skin-705x399.jpg 705w\" sizes=\"(max-width: 962px) 100vw, 962px\" \/><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-4l97er-de78a26d2bc81edd7ff6f8903da966aa\">\n.hr.av-4l97er-de78a26d2bc81edd7ff6f8903da966aa{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-4l97er-de78a26d2bc81edd7ff6f8903da966aa .hr-inner{\nwidth:50%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-4l97er-de78a26d2bc81edd7ff6f8903da966aa hr-custom  avia-builder-el-7  el_after_av_image  el_before_av_one_full  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bd' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-muoumco9-550ad675b4a793d2a00dee45617b549b\">\n#top .flex_column.av-muoumco9-550ad675b4a793d2a00dee45617b549b{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-muoumco9-550ad675b4a793d2a00dee45617b549b av_one_full  avia-builder-el-8  el_after_av_hr  el_before_av_hr  first flex_column_div av-zero-column-padding '   ><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h2 style=\"text-align: center;\">Moisturization &amp; Barrier Care<\/h2>\n<h3 style=\"text-align: center;\">Oxygen Signaling Awakens the Skin<\/h3>\n<p style=\"text-align: left;\"><strong>Harnessing the skin\u2019s own ability to generate and retain moisture.<br \/>\n<\/strong>OFC enhances the production of filaggrin and ceramides, supporting the moisturizing and barrier functions of the stratum corneum from within.<\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\"><strong>Promotion of Filaggrin Expression and Enzymes Involved in Ceramide Synthesis<\/strong><\/h3>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-muounfh2-0096e10559056d1df73f60c7e63aa8c4\">\n.avia-image-container.av-muounfh2-0096e10559056d1df73f60c7e63aa8c4 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muounfh2-0096e10559056d1df73f60c7e63aa8c4 av-styling- avia-align-center  avia-builder-el-11  el_after_av_textblock  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-6165 avia-img-lazy-loading-not-6165 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9-1030x372.jpg\" alt='' title='\u30af\u3099\u30e9\u30d51'  height=\"372\" width=\"1030\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9-1030x372.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9-300x108.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9-768x277.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9-1500x541.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9-705x254.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/56b2dfd60741d73ca2ca12f13b15cda9.jpg 1530w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>To maintain a healthy stratum corneum, both the ability to retain moisture and the ability to prevent moisture loss are essential.<br \/>\nFilaggrin serves as a precursor to Natural Moisturizing Factors (NMF) within the stratum corneum, helping support the skin\u2019s ability to retain moisture.<br \/>\nCeramides, on the other hand, fill the spaces between cells in the stratum corneum, helping reduce moisture loss while contributing to the skin\u2019s barrier function against external stressors.<br \/>\nIn studies using epidermal cells, OFC increased markers associated with filaggrin expression and ceramide production.<br \/>\nRather than simply providing temporary moisture to the skin surface, OFC is a cosmetic ingredient designed to support the skin\u2019s own mechanisms for generating and retaining moisture.<\/p>\n<\/div><\/section><br \/>\n<div  class='hr av-1y3x83-e471f2a276d3d8f93b6d3465368302aa hr-default  avia-builder-el-13  el_after_av_textblock  el_before_av_textblock  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><strong>Clinically Demonstrated Hydration and Barrier Benefits<\/strong><br \/>\nIn a human clinical study, OFC increased stratum corneum hydration to 3.5 times that of hyaluronic acid and reduced transepidermal water loss to 2.4 times the level observed with ceramide.<\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\"><strong>Results from a Repeated-Use Human Study<\/strong><\/h3>\n<p><strong>\u25aa\ufe0f Comparison with Other Ingredients (Human Efficacy Study)<\/strong><br \/>\nOFC was compared with hyaluronic acid (HA), widely known for its high water-retention capacity, and ceramide (CERA), known for its contribution to skin barrier function.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-muov4xo0-d6d87ae395b380c5ffcab612e9ccac56\">\n.avia-image-container.av-muov4xo0-d6d87ae395b380c5ffcab612e9ccac56 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muov4xo0-d6d87ae395b380c5ffcab612e9ccac56 av-styling- avia-align-center  avia-builder-el-16  el_after_av_textblock  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-6175 avia-img-lazy-loading-not-6175 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-1030x372.jpg\" alt='' title='\u30af\u3099\u30e9\u30d52'  height=\"372\" width=\"1030\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-1030x372.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-300x108.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-768x277.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-1536x554.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-1500x541.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b-705x254.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/123bd21535ad633bd8ec4fc41b8ed51b.jpg 1785w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>OFC does more than simply provide moisture to the skin. It acts on both the moisture-retaining function and the barrier function of the stratum corneum.<br \/>\nBy enhancing both \u201chydration,\u201d which increases moisture within the skin, and the \u201cbarrier,\u201d which helps prevent moisture loss, OFC was shown to support a healthy skin condition that is less prone to dryness.<\/p>\n<h6>*Internal data. N=7 (male and female subjects aged 20\u201350 years). Conducted in January 2025. Test formulations: carbomer gels containing each ingredient. Test site: forearm.<\/h6>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-251u4z-de33a816fcacf82827b4cb03f5fd2bd1\">\n.hr.av-251u4z-de33a816fcacf82827b4cb03f5fd2bd1{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-251u4z-de33a816fcacf82827b4cb03f5fd2bd1 .hr-inner{\nwidth:50%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-251u4z-de33a816fcacf82827b4cb03f5fd2bd1 hr-custom  avia-builder-el-18  el_after_av_one_full  el_before_av_one_full  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bd' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-2fun1v-6fbd3fc6a833fc56cf676973d5c11a5c\">\n#top .flex_column.av-2fun1v-6fbd3fc6a833fc56cf676973d5c11a5c{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-2fun1v-6fbd3fc6a833fc56cf676973d5c11a5c av_one_full  avia-builder-el-19  el_after_av_hr  el_before_av_textblock  first flex_column_div av-zero-column-padding '   ><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h2 style=\"text-align: center;\">Skin Irritation &amp; Oxidative Stress Care<\/h2>\n<h3 style=\"text-align: center;\">Supporting the Skin\u2019s Natural Antioxidant Defenses Against Oxidative Stress<\/h3>\n<p style=\"text-align: left;\">Two-Step Antioxidant Support: Direct Action on Hydroxyl Radicals and Enhanced Glutathione Production<\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\"><span style=\"text-align: left;\">Hydroxyl Radical Scavenging Activity Evaluated by ESR<\/span><\/h3>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" id=\"style-css-av-muovnlno-9f4a5ddd692aff915d06f7e482713633\">\n.avia-image-container.av-muovnlno-9f4a5ddd692aff915d06f7e482713633 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muovnlno-9f4a5ddd692aff915d06f7e482713633 av-styling- avia-align-center  avia-builder-el-22  el_after_av_textblock  el_before_av_textblock  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-6183 avia-img-lazy-loading-not-6183 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-1030x259.jpg\" alt='' title='\u30af\u3099\u30e9\u30d53\uff08OH\u30e9\u30b7\u3099\u30ab\u30eb\uff09'  height=\"259\" width=\"1030\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-1030x259.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-300x75.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-768x193.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-1536x386.jpg 1536w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-1500x376.jpg 1500w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed-705x177.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/03671bad25615f90e95cb7bd3fe7c7ed.jpg 1785w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Hydroxyl radicals are among the most highly reactive forms of reactive oxygen species (ROS) and are one of the factors that can cause oxidative damage to the skin.<br \/>\nUsing ESR (electron spin resonance), a technique that enables the detection of free radicals, OFC was shown to scavenge hydroxyl radicals.<br \/>\nOFC directly acts on oxidative stress factors once they are generated, helping protect and maintain a healthy skin environment.<\/p>\n<\/div><\/section><br \/>\n<div  class='hr av-6lp0kz-98d4c339489df9dee610fd1c127018f4 hr-default  avia-builder-el-24  el_after_av_textblock  avia-builder-el-last  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\">Enhanced Glutathione Production<\/h3>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-46t89v-b425aa466b5160c8d519a369e78fde7c\">\n#top .flex_column.av-46t89v-b425aa466b5160c8d519a369e78fde7c{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-46t89v-b425aa466b5160c8d519a369e78fde7c av_three_fifth  avia-builder-el-26  el_after_av_textblock  el_before_av_two_fifth  first flex_column_div av-zero-column-padding column-top-margin'   ><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p class=\"p1\">Glutathione is an important antioxidant produced within living epidermal cells, where it helps protect cells from oxidative stress.<br \/>\nIn a study with OFC, intracellular glutathione levels were increased.<br \/>\nOFC supports the skin\u2019s intrinsic antioxidant defense system from within, helping maintain skin that is more resilient to oxidative stress caused by external environmental factors.<\/p>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-bsasz-66d606ce8c55f632d09f6fed9be7bf75\">\n#top .flex_column.av-bsasz-66d606ce8c55f632d09f6fed9be7bf75{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-bsasz-66d606ce8c55f632d09f6fed9be7bf75 av_two_fifth  avia-builder-el-28  el_after_av_three_fifth  el_before_av_hr  flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-muovtne6-60d6cf9e7722d0fc1f13f01821024fef\">\n.avia-image-container.av-muovtne6-60d6cf9e7722d0fc1f13f01821024fef .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muovtne6-60d6cf9e7722d0fc1f13f01821024fef av-styling- avia-align-center  avia-builder-el-29  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-6187 avia-img-lazy-loading-not-6187 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/e54a3b158f85fd77cd06ffd2c876adaf-300x149.jpg\" alt='' title='\u30af\u3099\u30e9\u30d54\uff08\u30af\u3099\u30eb\u30bf\u30c1\u30aa\u30f3\uff09'  height=\"149\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/e54a3b158f85fd77cd06ffd2c876adaf-300x149.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/e54a3b158f85fd77cd06ffd2c876adaf-768x383.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/e54a3b158f85fd77cd06ffd2c876adaf-705x351.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/e54a3b158f85fd77cd06ffd2c876adaf.jpg 815w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div><\/div><\/div><\/div>\n<div  class='hr av-55y8eb-8e294f8b54868cb78d92594978a19077 hr-default  avia-builder-el-30  el_after_av_two_fifth  el_before_av_textblock  '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\">Results from a Repeated-Use Human Study<\/h3>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-4bqp5v-fe046c00e95f67f8b445ef381fd8a55e\">\n#top .flex_column.av-4bqp5v-fe046c00e95f67f8b445ef381fd8a55e{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-4bqp5v-fe046c00e95f67f8b445ef381fd8a55e av_one_half  avia-builder-el-32  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-muovxu52-0815298f7e6f80e6fb7a5982ad27391b\">\n.avia-image-container.av-muovxu52-0815298f7e6f80e6fb7a5982ad27391b .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muovxu52-0815298f7e6f80e6fb7a5982ad27391b av-styling- avia-align-center  avia-builder-el-33  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-6190 avia-img-lazy-loading-not-6190 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/29d3bc99193cb0b837fb8cc53f050ae5-1030x357.jpg\" alt='' title='\u753b\u50cf1'  height=\"357\" width=\"1030\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/29d3bc99193cb0b837fb8cc53f050ae5-1030x357.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/29d3bc99193cb0b837fb8cc53f050ae5-300x104.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/29d3bc99193cb0b837fb8cc53f050ae5-768x266.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/29d3bc99193cb0b837fb8cc53f050ae5-705x244.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/29d3bc99193cb0b837fb8cc53f050ae5.jpg 1292w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-1z92pf-1f8850804860d5860e7132b0606dd9fd\">\n#top .flex_column.av-1z92pf-1f8850804860d5860e7132b0606dd9fd{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-1z92pf-1f8850804860d5860e7132b0606dd9fd av_one_half  avia-builder-el-34  el_after_av_one_half  el_before_av_textblock  flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-muow57sg-ea19ce7b0cf4aa3ea375ec950a4acf57\">\n.avia-image-container.av-muow57sg-ea19ce7b0cf4aa3ea375ec950a4acf57 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muow57sg-ea19ce7b0cf4aa3ea375ec950a4acf57 av-styling- avia-align-center  avia-builder-el-35  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-6192 avia-img-lazy-loading-not-6192 avia_image' src=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/cbf5b9f60da99bf791c0aa12a770f429-1030x357.jpg\" alt='' title='\u753b\u50cf2'  height=\"357\" width=\"1030\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/cbf5b9f60da99bf791c0aa12a770f429-1030x357.jpg 1030w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/cbf5b9f60da99bf791c0aa12a770f429-300x104.jpg 300w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/cbf5b9f60da99bf791c0aa12a770f429-768x266.jpg 768w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/cbf5b9f60da99bf791c0aa12a770f429-705x244.jpg 705w, https:\/\/www.mediplus-pharma.co.jp\/_wordpress\/wp-content\/uploads\/2026\/10\/cbf5b9f60da99bf791c0aa12a770f429.jpg 1292w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/div><\/div><\/div><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Skin redness is one indicator used to assess disruptions in skin condition caused by factors such as dryness and external irritation.<br \/>\nPorphyrins are detected in association with sebum and the metabolic activity of the skin microbiota, and are used as an indicator for assessing the skin environment around the pores.<br \/>\nBy directly acting on hydroxyl radicals while also supporting the skin\u2019s intrinsic antioxidant defenses through enhanced glutathione production, OFC demonstrated the potential to help restore skin disrupted by external stressors to a healthier condition.<\/p>\n<h6>*Internal data. N=19 (male and female subjects aged 30\u201369 years). Conducted from November to December 2024. Test formulation: lotion containing 2% OFC. Test site: right cheek. Measurement device: VISIA.<\/h6>\n<\/div><\/section>\n\n<style type=\"text\/css\" id=\"style-css-av-3jlytv-d80bc043ddd6dd0db0e3ac81b490cf7a\">\n.hr.av-3jlytv-d80bc043ddd6dd0db0e3ac81b490cf7a{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-3jlytv-d80bc043ddd6dd0db0e3ac81b490cf7a .hr-inner{\nwidth:50%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-3jlytv-d80bc043ddd6dd0db0e3ac81b490cf7a hr-custom  avia-builder-el-37  el_after_av_textblock  el_before_av_one_full  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bd' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-2dleo3-0a48e2430e1ee899b5ff452a73a511aa\">\n#top .flex_column.av-2dleo3-0a48e2430e1ee899b5ff452a73a511aa{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-2dleo3-0a48e2430e1ee899b5ff452a73a511aa av_one_full  avia-builder-el-38  el_after_av_hr  el_before_av_hr  first flex_column_div av-zero-column-padding '   ><p>\n<style type=\"text\/css\" id=\"style-css-av-muow9dfo-c279fbe6348955ace00a38551346a7fa\">\n#top .av-special-heading.av-muow9dfo-c279fbe6348955ace00a38551346a7fa{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-muow9dfo-c279fbe6348955ace00a38551346a7fa av-special-heading-h2 blockquote modern-quote  avia-builder-el-39  el_before_av_textblock  avia-builder-el-first  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Versatility <span class='special_amp'>&amp;<\/span> Applications<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>As a water-soluble ingredient, OFC offers excellent formulation flexibility across O\/W and W\/O emulsions.<br \/>\nIt can be used in a wide range of applications, from cleansing and moisturizing to coverage products.<\/p>\n<p class=\"p1\"><strong>Recommended use level: 0.1\u20132%<\/strong><\/p>\n<p class=\"p1\">More than 2 million products containing OFC have already been produced over the past three years.<\/p>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-11parn-93b40a9f60baa0ea9982c285d6592465\">\n.hr.av-11parn-93b40a9f60baa0ea9982c285d6592465{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-11parn-93b40a9f60baa0ea9982c285d6592465 .hr-inner{\nwidth:50%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-11parn-93b40a9f60baa0ea9982c285d6592465 hr-custom  avia-builder-el-41  el_after_av_one_full  el_before_av_one_full  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bd' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-8pdn03-7415338386f8b219218505e9f72039d4\">\n#top .flex_column.av-8pdn03-7415338386f8b219218505e9f72039d4{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-8pdn03-7415338386f8b219218505e9f72039d4 av_one_full  avia-builder-el-42  el_after_av_hr  el_before_av_hr  first flex_column_div av-zero-column-padding '   ><p>\n<style type=\"text\/css\" id=\"style-css-av-muowcy2i-ed2cf4b4ea258c56dd761c46d0ba8a92\">\n#top .av-special-heading.av-muowcy2i-ed2cf4b4ea258c56dd761c46d0ba8a92{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-muowcy2i-ed2cf4b4ea258c56dd761c46d0ba8a92 av-special-heading-h2 blockquote modern-quote  avia-builder-el-43  el_before_av_textblock  avia-builder-el-first  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Safety<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock  '   itemprop=\"text\" ><p class=\"p1\">The following safety tests have been conducted to confirm the safety of OFC:<\/p>\n<p class=\"p1\"><em><strong>\u3000In vivo safety testing<\/strong><\/em><strong>\u3000\u30fb\u3000Mutagenicity testing\u3000\u30fb\u3000Human patch testing\u3001RIPT<br \/>\n<\/strong><\/p>\n<p>In addition, OFC has a long history of use, including \u3010<strong>over 20 years of use in skincare cosmetics since 2004<\/strong>\u3011<strong>and \u3010over 15 years of use in oral care cosmetics since 2011\u3011.<\/strong><\/p>\n<p class=\"p1\">To the best of our knowledge, no serious adverse events have been reported.<br \/>\nIn a dermatologist-supervised use test involving subjects with sensitive skin, no complaints of irritation or itching were observed.<\/p>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-7orwqb-05c6837471b587b0c41d354fc0f53415\">\n.hr.av-7orwqb-05c6837471b587b0c41d354fc0f53415{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-7orwqb-05c6837471b587b0c41d354fc0f53415 .hr-inner{\nwidth:50%;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-7orwqb-05c6837471b587b0c41d354fc0f53415 hr-custom  avia-builder-el-45  el_after_av_one_full  el_before_av_one_full  hr-center hr-icon-yes '><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue8bd' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-5u6kpv-7129b45f6c689f72f57dadb77db9c9f7\">\n#top .flex_column.av-5u6kpv-7129b45f6c689f72f57dadb77db9c9f7{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-5u6kpv-7129b45f6c689f72f57dadb77db9c9f7 av_one_full  avia-builder-el-46  el_after_av_hr  el_before_av_two_third  first flex_column_div av-zero-column-padding '   ><style type=\"text\/css\" id=\"style-css-av-muowhf0x-bc522d85b5a8055f43af548e5cc40c37\">\n#top .av-special-heading.av-muowhf0x-bc522d85b5a8055f43af548e5cc40c37{\npadding-bottom:10px;\n}\n<\/style>\n<div  class='av-special-heading av-muowhf0x-bc522d85b5a8055f43af548e5cc40c37 av-special-heading-h2 blockquote modern-quote  avia-builder-el-47  avia-builder-el-no-sibling  '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Overview<\/h2><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-4vxxpv-a5d4a37753cc6b105fb6cf363b1cd2fe\">\n#top .flex_column.av-4vxxpv-a5d4a37753cc6b105fb6cf363b1cd2fe{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-4vxxpv-a5d4a37753cc6b105fb6cf363b1cd2fe av_two_third  avia-builder-el-48  el_after_av_one_full  el_before_av_one_third  first flex_column_div av-zero-column-padding column-top-margin'   ><div class='avia-data-table-wrap av-t5t4kz-28605ed5a9643d5b531afd344b059579 avia_responsive_table avia-table-1 '><table  class='avia-table avia-data-table avia_pricing_default  avia-builder-el-49  avia-builder-el-no-sibling '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Table\" ><tbody><tr class=''><th class='avia-desc-col'><br \/>\nINCI Name<br \/>\nIngredient Name \/ Cosmetic Labeling Name<br \/>\nTrade Name<br \/>\n<\/th><td class=''><br \/>\nOzonized Glycerin<br \/>\nOzonized Glycerin<br \/>\nOzonated Functional Complex (OFC)<br \/>\n<\/td><\/tr><tr class=''><th class='avia-desc-col'><br \/>\nRecommended Use Level<br \/>\n<\/th><td class=''><br \/>\n0.1%\u20132%<br \/>\n<\/td><\/tr><tr class=''><th class='avia-desc-col'><br \/>\nOrigin<br \/>\n<\/th><td class=''><br \/>\n100% naturally derived, RSPO-certified<br \/>\n<\/td><\/tr><tr class=''><th class='avia-desc-col'><br \/>\nAppearance<br \/>\n<\/th><td class=''><br \/>\nClear, colorless, odorless liquid<br \/>\n<\/td><\/tr><tr class=''><th class='avia-desc-col'><br \/>\nApplications<br \/>\n<\/th><td class=''><br \/>\nSkin care and oral care<br \/>\n<\/td><\/tr><\/tbody><\/table><\/div><style type='text\/css'>.avia-table-1 td:nth-of-type(1):before { content: '\nINCI Name\nIngredient Name \/ Cosmetic Labeling Name\nTrade Name\n'; } <\/style><\/div>\n\n<style type=\"text\/css\" id=\"style-css-av-290l0z-bb953b74c26200638e1a90b39a70f098\">\n#top .flex_column.av-290l0z-bb953b74c26200638e1a90b39a70f098{\nborder-radius:0px;\n-webkit-border-radius:0px;\n-moz-border-radius:0px;\npadding:0px;\n}\n<\/style>\n<div class='flex_column av-290l0z-bb953b74c26200638e1a90b39a70f098 av_one_third  avia-builder-el-50  el_after_av_two_third  avia-builder-el-last  flex_column_div av-zero-column-padding column-top-margin'   ><style type=\"text\/css\" id=\"style-css-av-muowp3ch-e89e80aa2a1c2761fc3561239e20c1d5\">\n.avia-image-container.av-muowp3ch-e89e80aa2a1c2761fc3561239e20c1d5 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-muowp3ch-e89e80aa2a1c2761fc3561239e20c1d5 av-styling-no-styling avia-align-center  avia-builder-el-51  avia-builder-el-no-sibling  '  itemprop=\"image\" itemscope=\"itemscope\" 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