Advantages of ozone gel
Ozone gel as patented raw materials have anti-bacterial, anti-inflammatory, and wound healing effects.
Anti-bacterial effects of ozone gel
Ozone gel does not generate resistant bacteria, and a broad antibacterial spectrum is confirmed, such as gram-positive bacteria, gram-negative bacteria, yeast, and viruses. It is confirmed that ozone gel has effect on all species of bacteria (gram-positive bacteria, gram-negative bacteria, and albicans) except subtilis (good bacteria).
SEM image of e.coli
e.coli / not treated
e.coli / treated by Ozone Gel
bactericidal effect as a result of In vitro test

* Source: Bactericidal effect of ozone gel

Anti-inflammatory effects of ozone gel
Inhibiting inflammatory cytokines can prevent skin inflammation.


Research jointly conducted by Osaka Dental University and School of Dentistry of Showa University, and others

Using ozone gel diluted to 0.5ppm, the expression levels of interleukin IL-6 and IL-8 in the presence of porphyromonas gingivalis LPS (endotoxin) were measured by in-vitro.


This research found that ozone gel inhibited the expression of interleukin-6 and interleukin-8, kind of inflammatory cytokines, and had anti-inflammatory effects.

※Source: The Effect of Ozone on Collagen Type-1 and Inflammatory Cytokine Production in Human Gingival Fibroblasts

Wound healing effects of ozone gel
Promoting collagen production and accelerating wound healing


A study on wound healing using ozone ointment which was produced by adding macrogol ointment to ozone gel at the prosthodontics classroom of School of Dentistry of Showa University

Ozone ointment was applied twice a day to a wound site with a diameter of 5.0mm and a depth of about 1.0mm, and results were measured.


This study revealed that the reduction rate in case of application of ozone ointment was superior to the case of macrogol ointment and that the collagen fiber was densely arranged in findings of Azan staining.

Measurement Result of the wound site
(unit: mm)
Binding fibers on the wound surface
on the 7th day

In addition to the effects of promoting collagen production and accelerating wound healing, the effects of promoting immunostimulation and hyaluronic acid formation as well as fibroblast activation effects were confirmed.

*Source: A Histopathological Study of Wound Healing by Ozone Ointment Application