Shaping the future of the cosmetics and healthcare industries with the innovative ingredient, ozonized glycerin.

Mediplus Pharmaceuticals Co., Ltd. is at the forefront of supplying innovative ingredients for cosmetics and healthcare products, based on our patented component, ozonated glycerin. We strive to create new value in the healthcare market through advanced technology and the development of reliable products. Ozonated glycerin possesses a variety of functions, including anti-inflammatory properties and wound healing capabilities.

By promoting the expression of Nrf2, it enhances the cell’s inherent antioxidative and anti-inflammatory responses. Our research indicates its significant potential in not only skincare but also in antimicrobial effects, collagen production, and cellular proliferation. These characteristics hold great promise in product development, supporting consumer health and beauty.

Our efforts are underpinned by stringent quality control and continuous research and development. We provide information based on clinical data and scientific evidence for each product, ensuring the best ingredient supply to our business partners. Our expertise and technological prowess offer strong support to our clients, building robust partnerships to achieve success together in the market.

Mediplus Pharmaceuticals Co., Ltd. is shaping the future of the cosmetics and healthcare industries with our innovative ingredient, ozonated glycerin.

Whitening Care Safe for Ultra-Sensitive Skin | Unique Ingredient ‘Ozonated Glycerin’ Safe for Use with a History of Atopic Dermatitis

At Mediplus Pharmaceuticals, we have been advancing our research and development of unique ingredients like ozonated glycerin, aiming to alleviate symptoms of atopic dermatitis through the use of our ozonated glycerin products. Not only have we observed relief from atopic symptoms, but clinical studies have also confirmed improvements in dark spots and wrinkles.

Conclusion #1: Safe for Use on Atopic Skin

No subjects showed any worsening of skin irritation symptoms, such as itching or redness. Our findings suggest that the product is safe for use at all concentrations, even on atopic and dry skin.

(Testing Organization: S2 Research Lab Co., Ltd.)

Conclusion #2: Increased Moisture Levels in Atopic Skin Confirmed

An increase in the stratum corneum hydration at the application site was observed. Although patients with atopic dermatitis typically have reduced skin barrier function and thus lower skin moisture levels, an improvement trend was particularly noted in individuals with severe dryness and those undergoing treatment for atopic dermatitis.

(Testing Organization: S2 Research Lab Co., Ltd.)

Anticipated Products

The Effect of Ozone on Collagen Type-1 and Inflammatory Cytokine Production in Human Gingival Fibroblasts

Ozone is currently being considered as a possible oral antiseptic agent because it is strongly antimicrobial and does not induce microbial resistance. In the article, we examined the effects of ozone exposure on the production of collagen type-1 and inflammatory cytokines in primary human gingival fibroblasts (HGFs) in vitro using enzyme-linked immunosorbent assays. The addition of 0.5 ppm ozone significantly enhanced collagen type-1 production by HGFs within 24 h. Secretion of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-8 by HGFs treated with lipopolysaccharide decreased when ozone was present in the medium. Together, these results suggest that clinical use of ozone would facilitate the positive balance between HGF-mediated periodontal tissue maintenance

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