Methicillin
Methicillin is an antibiotic of the penicillin class. It is rarely used because it is unstable and difficult to handle in medical facilities.
Staphylococcus epidermidis
Staphylococcus epidermidis is a commensal bacterium found on human skin surfaces and in nasal cavities. It lacks the variety of toxins found in Staphylococcus aureus, but it can still cause infections particularly in individuals with implants and catheters.
Povidone-iodine
Povidone-iodine is an antiseptic used for skin disinfection. It is effective against Gram-positive bacteria, Gram-negative bacteria, tubercle bacillus, as well as fungi and some viruses. Additionally, it can be used continuously and is believed to be effective against drug-resistant bacteria.
Methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) is a kind of Staphylococcus aureus bacteria that demonstrate multidrug resistance to a variety of medications, including methicillin and other penicillin derivatives. It serves as the causative agent of methicillin-resistant Staphylococcus aureus infection (MRSA).
Liquid medium
A liquid medium is a solution in which nutrients necessary for the growth of microorganisms or biological tissues are dissolved in water.
Gas gangrene
Gas gangrene is a fatal infection caused by anaerobic bacteria such as Clostridium perfringens, which does not require oxygen for growth. These bacteria invade a wound and cause tissue necrosis. It is characterized by the production of gases such as methane and carbon dioxide, which spread the infection, rapidly causing widespread muscle necrosis and systemic poisoning symptoms such as circulatory failure, fever, and impaired consciousness.
Patents and Publications
PATENT
In 2001, our company pioneered the world’s first patented ingredient, Ozonized Glycerin, and has been exploring its potential ever since. After obtaining patents in 2004, over 100 papers have been published in academic journals and presented at conferences. Our research was recently featured on the “Journal of Cosmetic Dermatology” cover in 2022. Looking ahead, we’re committed to continuing our research and development as a trailblazing company in Ozonized Glycerin, striving to innovate superior manufacturing methods and applications.
Currently, we’ve secured four patents and numerous patent applications pending for further inventions and improvements in Japan and overseas. Our focus remains on strengthening the protection of our rights through patent registration.
4 registered patents: 6431251, 6671832, 7534001, 7575652
4 PCT applications filed: PCT/JP2022/031273, PCT/JP2024/29136, PCT/JP2024/026036, PCT/JP2024/21035
Three patent applications have been filed: 2024-204694, 2024-117854, 2024-89472
PUBLICATIONS
| Title | Journal | Year |
|---|---|---|
| The bactericidal effect of ozone gel | Showa Univ J Med Sci | 2004 |
| Application of ozone gel to the field of endodontics: A study of its bactericidal effect and cytotoxicity. | J Japan Endodontic Association, | 2012 |
| Antimicrobial effects of ozone gel on caries-causing bacteria. | Jpn J Conservative Dentistry, | 2013 |
| Effects of ozone gel on oral bacteria and its effects on human gingival and periodontal ligament fibroblasts. | Jpn J Conservative Dentistry, | 2014 |
| Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria. | Journal of Hard Tissue Biology 23[4] (2014) | 2014 |
| The Effect of Ozone on Collagen Type-1 and Inflammatory Cytokine Production in Human Gingival Fibroblasts. | Dentistry 2015 | 2015 |
| The Eｬ\ect of Ozone Gel on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2. | Journal of Hard Tissue Biology 27[3] (2018) | 2018 |
| Inactivation of SARS-CoV-2 by Ozonated Glycerol | Food and Environmental Virology (2021) | 2021 |
| Ozonized glycerin (OG)-based cosmetic products lighten age spots on human facial skin. | J Cosmet Dermatol. 2022 | 2022 |
| Comparative Study of Ozonated Glycerol and Macrogol Ointment on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2. | Materials 2023 | 2023 |