Ozonized Glycerin(Glycenergy) is a cosmetic ingredient made from glycerin that has been greatly enhanced to a highly functional ingredient through a patented “ozonation” process.

A novel, patented ozonation process was used to create zonized Glycerin(Glycenergy) , a new proprietary substance of natural origin made from glycerin that is gentle on the skin. This process was discovered during the drug discovery process.
Our newly-developed cosmetic ingredient was presented at the 2022 International Conference for the first time to the world. It was the result of research undertaken around 20 years by Mediplus Pharma Inc., which was established 50 years ago.

How is it different from conventional cosmetic ingredients?

Ozonized Glycerin(Glycenergy) can work omnidirectionally and effectively on the skin functions deteriorated by causal factors, including aging, dryness, and irritation. Thus, eliminating the causes of all types of skin problems.

What does “omnidirectional” mean?

Omnidirectional in this context refers to working on all the natural functions of the skin, as listed below.

(1) Ozonized Glycerin(Glycenergy) induces the upregulation of filaggrin, ceramides, and involucrin. Filaggrin is a central component of the natural moisturizing factor, which repairs the barrier function. Ceramides serve as intercellular lipids. Involucrin is a component of the cellular outer membrane structure.

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It has been verified that Ozonized Glycerin(Glycenergy)can upregulate the expression of filaggrin (left figure) and ceramides (right figure)compared with glycerin. Additionally, it has been demonstrated that “Glycenergy™” can activate many other constituents, including involucrin.

(2) It enhances the autophagy activity (LC3Ⅱ).
It activates autophagy (LC3Ⅱ), increases the quality of cell regeneration (differentiation), and promotes melanosome degradation.

It was shown that applying Ozonized Glycerin(Glycenergy) enhances the autophagy activity of skin cells.

(3) Anti-inflammatory and antioxidant functions via Nrf2 activation
It activates Nrf2, maintains skin homeostasis, increases the production of antioxidants called glutathione and HO-1 (heme oxygenase), and enhances the function of skin cells fighting oxidative stress and inflammation.

It was confirmed that Ozonized Glycerin(Glycenergy) increases glutathione (left figure) and HO-1 (right figure) levels compared with glycerin.

What can it do?

It can be used to design an appealing and optimal prescription for each brand as it is multifunctional, has a high performance, and is safe, thus being able to treat any skin problem.