Patents and Publications

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PATENT

In 2001, our company pioneered the world’s first patented ingredient, Ozonized Glycerin, and has been exploring its potential ever since. After obtaining patents in 2004, over 100 papers have been published in academic journals and presented at conferences. Our research was recently featured on the “Journal of Cosmetic Dermatology” cover in 2022. Looking ahead, we’re committed to continuing our research and development as a trailblazing company in Ozonized Glycerin, striving to innovate superior manufacturing methods and applications.

Currently, we’ve secured four patents and numerous patent applications pending for further inventions and improvements in Japan and overseas. Our focus remains on strengthening the protection of our rights through patent registration.

4 registered patents: 6431251, 6671832, 7534001, 7575652
4 PCT applications filed: PCT/JP2022/031273, PCT/JP2024/29136, PCT/JP2024/026036, PCT/JP2024/21035
Three patent applications have been filed: 2024-204694, 2024-117854, 2024-89472

PUBLICATIONS

TitleJournalYear
The bactericidal effect of ozone gel Showa Univ J Med Sci2004
Application of ozone gel to the field of endodontics: A study of its bactericidal effect and cytotoxicity.J Japan Endodontic Association,2012
Antimicrobial effects of ozone gel on caries-causing bacteria.Jpn J Conservative Dentistry,2013
Effects of ozone gel on oral bacteria and its effects on human gingival and periodontal ligament fibroblasts.Jpn J Conservative Dentistry,2014
Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria.Journal of Hard Tissue Biology 23[4] (2014) 2014
The Effect of Ozone on Collagen Type-1 and Inflammatory Cytokine Production in Human Gingival Fibroblasts.Dentistry 20152015
The Eｬ\ect of Ozone Gel on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2. Journal of Hard Tissue Biology 27[3] (2018)2018
Inactivation of SARS-CoV-2 by Ozonated GlycerolFood and Environmental Virology (2021)2021
Ozonized glycerin (OG)-based cosmetic products lighten age spots on human facial skin.J Cosmet Dermatol. 2022 2022
Comparative Study of Ozonated Glycerol and Macrogol Ointment on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2.Materials 20232023

Features of the cosmetic ingredient Ozonized Glycerin

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Ozonized Glycerin is a cosmetic ingredient made from glycerin that has been greatly enhanced to a highly functional ingredient through a patented “ozonation” process.

A novel, patented ozonation process was used to create zonized Glycerin , a new proprietary substance of natural origin made from glycerin that is gentle on the skin. This process was discovered during the drug discovery process.
Our newly-developed cosmetic ingredient was presented at the 2022 International Conference for the first time to the world. It was the result of research undertaken around 20 years by Mediplus Pharma Inc., which was established 50 years ago.

How is it different from conventional cosmetic ingredients?

Ozonized Glycerin can work omnidirectionally and effectively on the skin functions deteriorated by causal factors, including aging, dryness, and irritation. Thus, eliminating the causes of all types of skin problems.

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Features of Ozone Gel under development as a drug

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Our patented material, Ozone Gel, has antibacterial, anti-inflammatory, and wound healing effects

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